Protein name:
PRKC apoptosis WT1 regulator protein ;
Alternative:
Prostate apoptosis response 4 protein (Par-4) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with WT1, via the C-terminal region. Homooligomer. Interacts also with a wide variety of proteins, such as atypical PKCs, p62, DAPK3 kinase and THAP1. Interacts with actin, AATF, BACE1, SPSB1, SPSB2 AND SPSB4. Component of a ternary complex composed of SQSTM1 and PRKCZ.
Function:
Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
Subcellular Location:
Cytoplasm
Nucleus
Mainly cytoplasmic in absence of apoptosis signal and in normal cells. Nuclear in most cancer cell lines. Nuclear entry seems to be essential but not sufficient for apoptosis. Nuclear localization includes nucleoplasm and PML nuclear bodies.
Protein Attributes:
50:
MATGGYRSGG | STTTDFLEEW | KAKREKMRAK | QNPAGPGSSG | GDPAAKSPAG |
100:
SLTPTAVAGT | SELNHGPAGA | AAPAAPAPGA | LNCAHGSSTL | PRAAPGSRRA |
150:
EDECPSAAAA | SGAPGSRGDE | EEPDSAREKG | RSSGPSARKG | KGQIEKRKLR |
200:
EKRRSTGVVN | IPAAECLDEY | EDDEAGQKER | KREDAITQQN | TIQNEAATLP |
250:
DPGTSYLPQD | PSRTVPGRYK | STTSAPEDEI | SNRYPRTDRS | GFSRHNRDAN |
300:
APASFSSSST | LEKRIEDLEK | EVVRERQENL | RLVRLMQDKE | EMIGKLKEEI |
333:
DLLNRDLDDM | EDENEQLKQE | NKTLLKVVGQ | LTR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein
ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein
ELISA Kit for Mouse PRKC apoptosis WT1 regulator protein
CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein
CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein
CLIA Kit for Mouse PRKC apoptosis WT1 regulator protein
Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Polyclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Monoclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Monoclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Monoclonal Antibody for Mouse PRKC apoptosis WT1 regulator protein
Protein for Mouse PRKC apoptosis WT1 regulator protein
Protein for Mouse PRKC apoptosis WT1 regulator protein
Protein for Mouse PRKC apoptosis WT1 regulator protein
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
strain :
129S4/SvJae .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain :
C57BL/6 .
3.
Hackett J.D.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 137-333 (ISOFORM 1)
strain :
Swiss Webster / NIH .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN NEUROSYNAPTIC DEGENERATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SPSB1; SPSB2 AND SPSB4